We are developing a roll-to-roll (R2R) manufacturing technology for developing hybrid electronic systems on flexible substrates utilizing Ink-Jet printing. Compared to conventional electronics manufacturing based on cleanroom processes, printed electronics developed using roll-to-roll processes have several unique advantages such as low temperature processing on large area substrates with high throughput, environmentally friendly, low equipment and setup charges, hybrid system fabrication on a single substrate utilizing inorganic, organic and bio-inspired materials, utilization of cheap substrates, and development of truly flexible systems. Moreover, utilization of roll-to-roll compatible methods promise large area, low-cost manufacturing of light-weight, functional electronic devices that can be used in a wide variety of military and civilian applications.