Omega Optics, a leader in nanophotonics R&D, is developing novel chip-based technology that will revolutionize the world of portable, label-free bioassay devices.
Our most recent achievements and innovations in silicon-based “slow light” photonics enhances the effective optical path lengths and thereby enables miniaturization and higher detection sensitivity. With these breakthroughs, we are engineering a platform technology of highly sensitive, flexible, portable, multiplexed and cost-effective “lab-on- chip” solutions that will soon disrupt portable bioassay markets.
Our patented (and patent-pending) technologies can power highly-sensitive portable (or bench-top) devices for biosensing applications including:
• Detection of heavy metals, VOCs and TICs in water
• Pathogen detection in Food & Beverage
• Early cancer biomarkers
• Infectious diseases
• Antibiotic monitoring
• Pharmaceutical drug discovery
• Our proprietary microarray design allows for up to 128/256 different targets and controls to be tested simultaneously on the same chip
• Total sample volume of only 100μl required for all 128/256 targets and controls
• Detects any biomolecule (proteins, DNA, mRNA, small molecules) via conjugate affinity with high specificity and high sensitivity
• In-situ results in less than 30 minutes with rugged, portable, easy-to-use devices
The development of a benchtop platform program was supported by a SBIR contract (Phase 1 and Phase 2) from the National Cancer Institute (NCI/ NIH)
• S. Chakravarty, X. Chen, N.Tang, W-C. Lai, Y. Zou, H. Yan, R. T. Chen, “Review of design principles of 2D photonic crystal microcavity biosensors in silicon and their applications” , Frontiers of Optoelectronics 9(2), 206 (2016).
• S. Chakravarty, W-C. Lai, Y. Zou, H.A. Drabkin, G.R. Simon, S.H. Chin, R. M. Gemmill, R.T. Chen, “Multiplexed Specific Label-Free Detection of NCI-H358 Lung Cancer Cell Line Lysates with Silicon Based Photonic Crystal Microcavity Biosensors”, Biosens. Bioelectron. 43, 50 (2013).
Preliminary development of handheld platform program was supported by a DOE SBIR contract (Phase 1).
• H. Yan, N. Tang, S. Chakravarty, R. T. Chen, ” High-sensitivity high-throughput chip based biosensor array for multiplexed detection of heavy metals, ” in BiOS (Photonics West), San Francisco, California, United States (2016) (oral)
Preliminary development was supported by a US ARMY SBIR contract (Phase 1).
• H. Yan, C-J. Yang, Y. Zou, N. Tang, S. Chakravarty, R. T. Chen, “Wide Dynamic Range Specific Detection of Therapeutic Drugs by Photonic Crystal Microcavity Arrays” in CLEO (Optical Society of America), Abstract ID: STu4K.2, San Jose, CA (2015)
We completed Phase 1 of a NCI/NIH supported contract for the development of an integrated platform for the isolation and enrichment of exosomes, microRNA extraction and high-sensitvity lab-on-chip detection. Results to appear soon.